An in Silico Study of Novel Fluoroquinolones as Inhibitors of Dna Gyrase of Staphylococcus Aureus
نویسندگان
چکیده
Methods: Structure of DNA gyrase (2XCT) was retrieved from the Protein Data Bank (PDB) and the structures of (FQ) compounds were selected from literature survey of 400 novel compounds and the physical, chemical and molecular characteristics of each compound were obeyed for drugrelevant properties based on “Lipinski’s rule of five, then a total of 150 (FQ)s were docked against the protein of the 2XCT enzyme.
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Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus.
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